Newly developed drug delivery system combined with anti-inflammatory drugs shows promise in lab experiments
A newly synthesised biocompatible therapeutic nano-micelle drug delivery system combined with anti-inflammatory drugs has demonstrated significant potential in the treatment of rheumatoid arthritis (RA). The innovative approach not only alleviates pain associated with the disease but also restores cartilage integrity, providing flexibility to the affected joints.
Rheumatoid arthritis is characterized by inflammation that plays a pivotal role in its development. Current treatment strategies primarily focus on providing symptomatic relief, with no permanent cure available. However, scientists from the Institute of Nano Science and Technology (INST), Mohali, have made strides in exploring alternative drugs or strategies to combat the disease.
Innovative Approach: Nano-Micelle Loaded with Anti-Inflammatory Drug Offers New Hope for RA Patients
Led by Dr. Rehan Khan, a research group at INST, along with Senior Research Fellow Mr. Akshay Vyawahare, developed a therapeutic nano-micelle loaded with an anti-inflammatory drug known as 9-aminoacridine (9AA). This drug specifically inhibits inflammatory mediators by activating the NR4A1 gene, which regulates the inflammatory mechanism by suppressing pro-inflammatory cytokines. The nano-micelle itself exhibits therapeutic effects, but when combined with the anti-inflammatory drug, it demonstrates enhanced potential in experimental models of rheumatoid arthritis by inhibiting joint damage and cartilage degradation.
Safe and Cost-Effective Solution: Therapeutic Nano-Micelle Holds Promise for Rheumatoid Arthritis Treatment
The simplicity, cost-effectiveness, safety, and translational potential of this drug delivery system make it a promising avenue for future treatment. While the nano-formulation has been tested on rats and published in ACS Nano, it holds the potential to provide long-term relief for numerous rheumatoid arthritis patients by reducing disease severity and protecting against its reappearance.
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